Computational Biology

Specificity, synergy, and mechanisms of splice-modifying drugs
Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is …
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Structural and mechanistic basis of σ-dependent transcriptional pausing
In σ-dependent transcriptional pausing, the transcription initiation factor σ, translocating with RNA polymerase (RNAP), makes …
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MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect
Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep mutational scanning experiments on proteins and …
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Novel tool to quantify with single-cell resolution the number of incoming AAV genomes co-expressed in the mouse nervous system
Adeno-associated viral (AAV) vectors are an established and safe gene delivery tool to target the nervous system. However, the payload …
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Periodicity Scoring of Time Series Encodes Dynamical Behavior of the Tumor Suppressor p53
In this paper we analyze the dynamical behavior of the tumor suppressor protein p53, an essential player in the cellular stress …
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