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Characterization of partial wetting by CMAS droplets using multiphase many-body dissipative particle dynamics and data-driven discovery based on PINNs
The molten sand that is a mixture of calcia, magnesia, alumina and silicate, known as CMAS, is characterized by its high viscosity, …
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Specificity, synergy, and mechanisms of splice-modifying drugs
Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is …
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Machine-learning-based data-driven discovery of nonlinear phase-field dynamics
One of the main questions regarding complex systems at large scales concerns the effective interactions and driving forces that emerge …
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On the parameter combinations that matter and on those that do not: data-driven studies of parameter (non)identifiability
We present a data-driven approach to characterizing nonidentifiability of a model’s parameters and illustrate it through dynamic as …
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Structural and mechanistic basis of σ-dependent transcriptional pausing
In σ-dependent transcriptional pausing, the transcription initiation factor σ, translocating with RNA polymerase (RNAP), makes …
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MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect
Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep mutational scanning experiments on proteins and …
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Novel tool to quantify with single-cell resolution the number of incoming AAV genomes co-expressed in the mouse nervous system
Adeno-associated viral (AAV) vectors are an established and safe gene delivery tool to target the nervous system. However, the payload …
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Numerical simulation of atomic layer deposition for thin deposit formation in a mesoporous substrate
ZnO deposition in porous γ-Al2O3 via atomic layer deposition (ALD) is the critical first step for the fabrication of zeolitic …
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Periodicity Scoring of Time Series Encodes Dynamical Behavior of the Tumor Suppressor p53
In this paper we analyze the dynamical behavior of the tumor suppressor protein p53, an essential player in the cellular stress …
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Emergent spaces for coupled oscillators
Systems of coupled dynamical units (e.g., oscillators or neurons) are known to exhibit complex, emergent behaviors that may be …
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